TECHNOLOGY

Mode of Action

FIBREX Medical has conclusively demonstrated that leukocyte transmigration is critically controlled by fibrin fragments. These short lived intermediates engage leukocytes to the endothelial cell junction, which breaks up the VE-cadherin interaction between neighbouring endothelial cells. This interaction allows the leukocyte to pass through into the tissue (diapedesis).

FIBREX Medical´s anti-inflammatory peptide FX06 prevents this interaction between fibrin fragments and VE-cadherin.