FIBREX Medical

NEWS: Publications



Quantification of elemental labeled peptides in cellular uptake studies

Koellensperger G, Groeger M, Zinkl D, Petzelbauer P, Hann S

J. Anal. At. Spectrom., 2009, 24, 97–102

www.fibrexmedical.com/pdf/JAAS_FX_2009.pdf

Original Article in 'JAAS' (subscription required):
www.rsc.org/publishing/journals/JA/article.asp?doi=b807397j



Peptide Bß15-42 Preserves Endothelial Barrier Function in Shock

Gröger M, Pasteiner W, Ignatyev G, Matt U, Knapp S, Atrasheuskaya A, Bukin E, Friedl P, Zinkl D, Hofer-Warbinek R, Zacharowski K, Petzelbauer P, Reingruber S

PLoS ONE 4(4): e5391. doi:10.1371/journal.pone.0005391

www.fibrexmedical.com/pdf/PLoS_ONE_4_2009.pdf
or
http://dx.plos.org/10.1371/journal.pone.0005391



Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction

Results of the F.I.R.E. (Efficacy of FX06 in the prevention of myocardial reperfusion injury) trial

Atar D, Petzelbauer P, Schwitter J, Huber K, Rensing B, Kasprzak JD, Butter C, Grip L, Hansen PR, Süselbeck T, Clemmensen PM, Marin-Galiano M, Geudelin B, Buser BT, for the F.I.R.E. Investigators

Journal of the American College of Cardiology (2009) 53:720-729

www.fibrexmedical.com/pdf/JACC_2009.pdf



15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion

Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Vagts DA, Scheeren TWL, Vollmar B, Nöldge-Schomburg GEF, Zacharowski, K

Crit Care Med 2009 Vol. 37, No. 2

www.fibrexmedical.com/pdf/CCM_2009.pdf



A double blind, single centre, sub-chronic reperfusion trial evaluating FX06 following haemorrhagic shock in pigs

Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Mutz C, Vollmar B, Nöldge-Schomburg GEF, Zacharowski K

Resuscitation 2009; 80:264–271

www.fibrexmedical.com/pdf/Resuscitation_2009.pdf



The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury

Roesner JP, Petzelbauer P, Koch A, Mersmann J, Zacharowski PA, Boehm O, Reingruber S, Pasteiner W, Mascher HD, Wolzt M, Barthuber C, Noldge-Schomburg GE, Scheeren TW, Zacharowski K

Crit Care Med. 2007 May 22, Epub Ahead of Print

PubMed Abstract:
www.ncbi.nlm.nih.gov/entrez/
query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17522584

Original Article in 'Crit Care Med' (subscription required):
www.ccmjournal.com/pt/re/ccm/abstract.00003246-900000000-99646.htm



The effects of the fibrin-derived peptide Bbeta15-42 in acute and chronic rodent models of myocardial ischemia-reperfusion

Zacharowski K, Zacharowski PA, Friedl P, Mastan P, Koch A, Boehm O, Rother RP, Reingruber S, Henning R, Emeis JJ, Petzelbauer P

Shock. 2007 Jun;27(6):631-63

PubMed Abstract:
www.ncbi.nlm.nih.gov/entrez/
query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17505302

Original Article in 'Shock' (subscription required):
www.shockjournal.com/pt/re/shock/abstract.00024382-200706000-00007.htm



Neue Überlegungen zu Entzündung und Gerinnung
[New reflections on inflammation and coagulation]

Zacharowski, K

Der Anaesthesist. 2007 Mar 16 (DOI: 10.1007/s00101-007-1163-3)

PubMed Abstract:
www.ncbi.nlm.nih.gov/entrez/
query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17364187

Original Article in 'Der Anaesthesist' (subscription required):
www.springerlink.com/content/p744477r3326k618/?typ=fulltext&file=CRD2007108002117



FX06 (fibrin-derived peptide Bbeta15-42) - A potential candidate for myocardial reperfusion therapy

Henning R, Zacharowski K, Petzelbauer P

Drugs Fut. 2006, 31(9): 811-818 (DOI: 10.1358/dof.2006.031.09.1025670)

Abstract and link to original article in 'Drugs of the Future': http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?
p_JournalId=2&p_RefId=1025670&p_IsPs=N



Rationale and Design of the 'F.I.R.E.' Study.
A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Measure the Effect of FX06 (a Fibrin-Derived Peptide Bbeta(15-42)) on Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Atar D, Huber K, Rupprecht HJ, Kopecky SL, Schwitter J, Theek C, Brandl K, Henning R, Geudelin B.

Cardiology 2006 Oct 2;108(2):117-123 (DOI: 10.1159/000095982)

PubMed Abstract:
www.ncbi.nlm.nih.gov/entrez/
query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17019083

Original Article in Cardiology (subscription required):
http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=CRD2007108002117



Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction

Zacharowski K, Zacharowski P, Reingruber S, Petzelbauer P

J. Mol. Med. 2006 June;84(6):469-477

PubMed Abstract:
www.ncbi.nlm.nih.gov/entrez/
query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16733765  

Original Article in J. Mol. Med. (subscription required):
http://dx.doi.org/10.1007/s00109-006-0051-7



The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury.

Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, Castellino FJ, Groger M, Wolff K, Zacharowski K.

Nat. Med. 2005 Mar;11(3):298-304

PubMed Abstract:
www.ncbi.nlm.nih.gov/entrez/
query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15723073

Original Article in Nature Medicine (subscription required):
www.nature.com/nm/journal/v11/n3/index.html




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